Retinal toxicity of moxifloxacin injected intravitreally into rabbit eyes
Leandro Jose G. Domalanta, MD, Alex S. Sua, MD, Jocelyn L. Sy, MD
Objective
To investigate the retinal toxicity of different doses of moxifloxacin after intravitreal injection into rabbit eyes.
Methods
Eight male rabbits were divided into four groups; 2 rabbits each were injected intravitreally with moxifloxacin 48 µg, 240 µg, 480 µg, and normal saline solution. Ocular toxicity was assessed at day 3 and day 7 by slit-lamp
biomicroscopy, ophthalmoscopy, and histology.
Results
All eyes showed no abnormalities on histologic evaluation. No relevant complications were found during slit-lamp biomicroscopy and indirect ophthalmoscopy.
Conclusion
Intravitreal injection of 480 µg or less of moxifloxacin did not produce retinal toxicity histologically in rabbit eyes.
Keywords: Endophthalmitis, Retinal toxicity, Moxifloxacin, Intravitreal injection