Methanol-induced bilateral optic neuropathy

Objective
To emphasize the importance of diagnosing cases of methanol toxicity, demonstrate the value of electrophysiologic testing as an adjunct in the diagnosis, and provide a framework for intervention.

Methods
This is a case report.

Results
The patient’s visual-evoked-response tracing showed failure of transmission while electroretinogram waveforms were normal. The findings were consistent with bilateral optic neuropathy from ingestion of methanol.

Conclusion
Complete clinical history and ophthalmologic examination are vital to the diagnosis of methanol toxicity. Respiratory assessment and support and treatment of acidosis are the cornerstone of its management. Currently, the primary therapeutic approach is the use of competitive inhibitors of alcohol dehydrogenase.

Keywords: Methanol toxicity, Methanol-induced optic neuropathy, Alcohol-related ocular toxicity