The Antimicrobial Efficacy of Multipurpose Contact Lens Solutions on Standard Strains of Common Ocular Pathogens

To compare the antimicrobial effects of locally available multipurpose contact lens solutions (MPS) on the growth of standard strains of contact lens-related ocular pathogens and to establish the recommended duration of exposure to these solutions to achieve maximal antimicrobial efficacy.

This study, a single-blind controlled experiment, evaluated five locally available MPS in terms of their antimicrobial efficacy towards common contact lens-related ocular pathogens, such as P. aeroginosa, S. aureus, E. coli, F. solani, and C. albicans, using the stand alone criteria. Microbial viability counts were obtained at serial durations: after 1 hour, 3 hours, 6 hours, and 12 hours of exposure.

MPS containing polyquaternium-1 and myristamidopropyl dimethylamine (MAPD) and polyhexamide reduced the bacterial concentrations by 3 log and fungal concentrations by 1 log, enabling them to fulfill the stand alone criteria for disinfecting solutions as mandated by ISO/CD 14729. This antimicrobial efficacy was most evident at 6 hours of exposure to the challenge organisms. MPS containing polyquaternium-1 and MAPD also have the broadest spectrum of effectivity against gram-negative and gram-positive bacteria, and C. albicans. All MPS tested have poor microbial activity against F. solani.

Multipurpose contact lens solutions demonstrated variability in their antimicrobial activity. MPS with broad spectrum efficacy and effectivity, such as those containing polyquaternum and MAPD, are preferred to prevent contact lens-related ocular infections.

Contact lens, Multipurpose contact lens solutions, Microbial keratitis, Infectious keratitis, Silicon hydrogels