Epithelial-Myoepithelial Carcinoma of the Lacrimal Gland – Case Report and Review of Literature
Mara Augustine S. Galang MD1, Gary John V. Mercado MD1,2, Armida L. Suller-Pansacola MD1,2,3, Jose M. Carnate Jr. MD4,5
1Department of Ophthalmology, Manila Doctors Hospital, Manila, Philippines
2Department of Ophthalmology and Visual Sciences, College of Medicine, University of the Philippines- Philippine General Hospital, Manila, Philippines
3Department of Ophthalmology, University of Santo Tomas Hospital, Manila, Philippines
4Department of Laboratory Medicine, Manila Doctors Hospital, Manila, Philippines
5Department of Pathology, College of Medicine, University of the Philippines-Philippine General Hospital, Manila, Philippines
Correspondence: Mara Augustine S. Galang, MD
Office Address: Department of Ophthalmology, Manila Doctors Hospital, 667 United Nations Avenue, Ermita, Manila, Philippines
Office Phone Number: +63 2 85580888 local 0557
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Disclosure: The authors report no financial conflict of interest.
Objective: To describe the clinicopathologic features and outcome of a patient with epithelial-myoepithelial carcinoma of the lacrimal gland who underwent modified lateral orbitotomy with en toto removal of the lesion and adjuvant radiotherapy.
Methods: This is a case report.
Results: A 31-year-old Filipino male seafarer presented with a 2-month history of an enlarging left superotemporal orbital mass and inferonasal displacement of the globe. Magnetic resonance imaging revealed a superotemporal extraconal mass within the lacrimal sac fossa with evidence of osseous infiltration of the superolateral orbital rim. Modified lateral orbitotomy was performed with en toto removal of the lesion and the clinically infiltrated adjacent lateral bony margin. Histopathologic diagnosis of epithelial-myoepithelial carcinoma of the lacrimal gland was made based on the classic and distinct biphasic morphology and was confirmed with immunohistochemistry studies (cytokeratin-7, S-100, and p63). Systemic surveillance using positron emission tomography and computed tomography scan with contrast revealed no evidence of regional or distant metastasis. Adjuvant radiotherapy of the orbital area was performed for increased local control. Twelve months postoperatively, the patient showed no evidence of tumor recurrence.
Conclusion: Epithelial-myoepithelial carcinoma of the lacrimal gland is a rare condition, and this is the first documented case from the Philippines. Accurate diagnosis is necessary for appropriate treatment. It should be included in the differential diagnosis of infiltrative lesions in the lacrimal gland fossa.
Keywords: epithelial-myoepithelial carcinoma, lacrimal gland, clinicopathologic features, outcome, orbitotomy