Effect of sibutramine on intraocular pressure
Ahmet Satici, MD, Nevin Yilmaz, MD, Mustafa Guzey, MD, Adil Kilic, MD
Objective
This study evaluated the effects of sibutramine on intraocular pressure (IOP) and body-mass index (BMI).
Methods
Thirty obese females (body-mass index >30 kg/m2 ) treated with sibutramine (10 mg/day) plus diet restriction for 3 months were included in the study. IOP, BMI, and blood biochemical parameters were measured at the beginning and end of the treatment. Results were evaluated statistically by paired t-test, analysis of variance, and least-significant difference test.
Results
A statistically significant decrease was observed in the mean body-mass index (p < 0.001) and serum triglyceride (p < 0.001), while a statistically insignificant increase was observed in IOP (p = 0.54).
Conclusion
While sibutramine provided an effective means for weight loss, it caused a s l ight inc rea se in IOP, a l though thi s wa s not s t a t i s t i c a l l y s igni f i c ant . Nevertheless, it is prudent to monitor IOP in selected obese patients treated with sibutramine.
Keywords: Intraocular pressure, Obesity, Sibutramine