In vitro evaluation of natamycin 5% suspension against Aspergillus flavus, Fusarium solani, and Candida parasilopsis

Authors

  • Farlah Angela M. Salvosa, MD Department of Ophthalmology and Visual Sciences University of the Philippines Philippine General Hospital Manila Author
  • Leo P. Cubillan, MD Department of Ophthalmology and Visual Sciences University of the Philippines Philippine General Hospital Manila Author
  • Mrs. Lilia Flor Nievera, RMT Department of Ophthalmology and Visual Sciences University of the Philippines Philippine General Hospital Manila Author

Abstract

Objective: This study compared the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of two available brands of natamycin 5% suspension (Natacyn and Elmycin) against three ocular fungi (Aspergillus flavus, Candida parasilopsis, Fusarium solani).

Methods: Antifungal susceptibility testing by broth microdilution was performed. The MIC and MFC of both brands were determined and paired t-tests were compared.

Results: Results of MIC and MFC of Elmycin and Natacyn against Aspergillus flavus showed no significant difference (p = 0.05). The same values were obtained for Fusarium solani and Candida parasilopsis, showing no difference in their MIC and MFC.

Conclusion: Elmycin and Natacyn have similar MIC and MFC against Aspergillus flavus, Fusarium solani, and Candida parasilopsis as determined by in vitro tube dilution technique. Elmycin may be used as an alternative agent against these organisms in fungal keratitis.

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Published

2004-03-01

Issue

Vol. 29 No. 1

Section

Original Article

License

Copyright (c) 2004 Philippine Journal of Ophthalmology

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.