Retinal toxicity of moxifloxacin injected intravitreally into rabbit eyes

Leandro Jose G. Domalanta, MD; Alex S. Sua, MD; Jocelyn L.  Sy, MD

Authors

Leandro Jose G. Domalanta, MD University of Santo Tomas Hospital Manila, Philippines Author
Alex S. Sua, MD University of Santo Tomas Hospital Manila, Philippines Author
Jocelyn L. Sy, MD University of Santo Tomas Hospital Manila, Philippines Author

Keywords:

Endophthalmitis, Retinal toxicity, Moxifloxacin, Intravitreal injection

Abstract

Objective: To investigate the retinal toxicity of different doses of moxifloxacin after intravitreal injection into rabbit eyes.

Methods: Eight male rabbits were divided into four groups; 2 rabbits each were injected intravitreally with moxifloxacin 48 µg, 240 µg, 480 µg, and normal saline solution. Ocular toxicity was assessed at day 3 and day 7 by slit-lamp biomicroscopy, ophthalmoscopy, and histology.

Results: All eyes showed no abnormalities on histologic evaluation. No relevant complications were found during slit-lamp biomicroscopy and indirect ophthalmoscopy.

Conclusion: Intravitreal injection of 480 µg or less of moxifloxacin did not produce retinal toxicity histologically in rabbit eyes.