A case of intracranial chordoma associated with multiple-cranial-nerve palsy

Abstract

Objective: To report a case of intracranial chordoma associated with multiple-cranial-nerve palsies, highlight its presenting features, and evaluate treatment options for this rare neoplasm.

Methods: This is a case report.

Results: A 77-year-old man presented with diplopia and left sixth-nerve palsy. Further investigations revealed an intracranial chordoma. Surgical decompression was performed which resulted in complete resolution of the diplopia. Three months postsurgery, he was noted to have a right-third-nerve palsy. Repeat MRI showed tumor recurrence. Targeted proton-beam-charged-particle therapy was performed.

Conclusion: Radiation therapy using targeted proton-beam-charged particle was shown effective in the treatment of intracranial chordoma, resulting in significant improvement in ocular motility and resolution of ptosis.