Toxic epidermal necrolysis

Rosalie Mae M. Reyes, MD; Jacinto Dy Liacco, MD

Authors

Rosalie Mae M. Reyes, MD Department of Ophthalmology and Visual Sciences University of the Philippines– Philippine General Hospital Manila, Philippines Author
Jacinto Dy-Liacco, MD Department of Ophthalmology and Visual Sciences University of the Philippines– Philippine General Hospital Manila, Philippines Author

Keywords:

Toxic epidermal necrolysis, Adverse drug reaction, Scalded-skin syndrome

Abstract

Objective: To recognize the common ocular signs and symptoms of toxic epidermal necrolysis (TEN), differentiate it from similar diseases, give the appropriate management, and provide continuity of care.

Methods: This is a case report of a 21-year-old female patient admitted for ocular involvement of TEN secondary to an acute food reaction and an adverse drug reaction to intravenous cloxacillin.

Results: The patient had hyperemic conjunctivae with infiltration, mucopurulent discharge, and pseudomembrane formation with a corneal epithelial defect. The ocular symptoms were treated with copious irrigation of the conjunctival sac, daily membrane peeling, topical antibiotics, and topical steroids. The patient was advised regular follow-up to prevent symblepharon formation.

Conclusion: With the appropriate diagnosis and management of TEN, ocular symptoms may be relieved and complications prevented.